{"id":4600,"date":"2024-07-27T18:06:13","date_gmt":"2024-07-27T16:06:13","guid":{"rendered":"https:\/\/orl-chu-caen.fr\/?page_id=4600"},"modified":"2024-08-23T21:20:21","modified_gmt":"2024-08-23T19:20:21","slug":"dr-stephane-besnard","status":"publish","type":"page","link":"https:\/\/orl-chu-caen.fr\/?page_id=4600","title":{"rendered":"Dr. St\u00e9phane BESNARD"},"content":{"rendered":"[et_pb_section fb_built=\u00a0\u00bb1″ _builder_version=\u00a0\u00bb4.16″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_row column_structure=\u00a0\u00bb2_5,3_5″ _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_padding=\u00a0\u00bb|0px||||\u00a0\u00bb box_shadow_style=\u00a0\u00bbpreset1″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_5″ _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_team_member name=\u00a0\u00bbDr St\u00e9phane BESNARD\u00a0\u00bb position=\u00a0\u00bbMa\u00eetre de Conf\u00e9r\u00e9rence Universitaire – Praticien Hospitalier\u00a0\u00bb image_url=\u00a0\u00bbhttps:\/\/orl-chu-caen.fr\/wp-content\/uploads\/2024\/07\/besnard-1.jpg\u00a0\u00bb _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_font=\u00a0\u00bbAbel||||||||\u00a0\u00bb header_font_size=\u00a0\u00bb34px\u00a0\u00bb body_text_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb body_font_size=\u00a0\u00bb15px\u00a0\u00bb position_font=\u00a0\u00bbAbel||||||||\u00a0\u00bb position_font_size=\u00a0\u00bb21px\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb custom_padding=\u00a0\u00bb||3px|||\u00a0\u00bb border_width_all=\u00a0\u00bb15px\u00a0\u00bb border_color_all=\u00a0\u00bb#FFFFFF\u00a0\u00bb border_width_all_image=\u00a0\u00bb9px\u00a0\u00bb border_color_all_image=\u00a0\u00bb#d2d0bb\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]

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Explorations vestibulaires et neurophysiologiques<\/h3>[\/et_pb_team_member][\/et_pb_column][et_pb_column type=\u00a0\u00bb3_5″ _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bbAbel||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb19px\u00a0\u00bb text_line_height=\u00a0\u00bb1em\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_font_size=\u00a0\u00bb17px\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb custom_padding=\u00a0\u00bb0px|||||\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ inline_fonts=\u00a0\u00bbAbel\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb border_width_all=\u00a0\u00bb16px\u00a0\u00bb border_color_all=\u00a0\u00bbRGBA(255,255,255,0)\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″]

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FORMATION ET TITRES<\/h2>\n

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Ma\u00eetre de Conf\u00e9rence des Universit\u00e9s (M.C.U.)<\/p>\n

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Praticien Hospitalier (P.H.)<\/p>\n

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Docteur en M\u00e9decine (M.D.)<\/p>\n

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Docteur en Neuroscience\u00a0 (Ph.D)<\/p>\n

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Habilitation \u00e0 Diriger les Recherches (HDR)<\/p>\n

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Ancien Assistant des H\u00f4pitaux<\/p>\n

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Ancien Interne des H\u00f4pitaux<\/p>\n

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Capacit\u00e9 de M\u00e9decine A\u00e9ronautique et Spatiale<\/p>\n

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D.I.U. de M\u00e9decine Subaquatique et Hyperbare<\/p>\n

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SOCIETES SAVANTES<\/h2>\n

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Membre de la Soci\u00e9t\u00e9 Internationale d’Otoneurologie<\/a><\/p>\n

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Membre du comit\u00e9 de pilotage du\u00a0 Groupe De Recherche \u00ab\u00a0Vertige\u00a0\u00bb (GDR)<\/a><\/p>\n

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Membre du conseil Scientifique de la Soci\u00e9t\u00e9 de Physiologie<\/a><\/p>\n

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Membre du conseil scientifique de l’Adaptation Institute<\/a><\/p>\n

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DISCIPLINES<\/h2>\n

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Physiologie<\/p>\n

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Neurophysiologie et M\u00e9decine en milieux extr\u00eames<\/p>\n

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Explorations Vestibulaires<\/p>\n

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T\u00e9l\u00e9m\u00e9decine<\/p>\n

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RECHERCHE<\/h2>\n

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Chercheur au Laboratoire UR VERTEX 7480<\/a><\/p>\n

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Chercheur au Laboratoire de Neurosciences Sensorielles et Cognitives (CNRS- Aix-Marseille)<\/a><\/p>\n

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Ancien Chercheur \u00e0 INSERM U 1075 – COMETE<\/em> – \u00abCOgnition, Mobilit\u00e9, Equilibre, TEmporalit\u00e9 \u00bb<\/a><\/p>\n

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Investigateur Principal pour diff\u00e9rents programmes de recherche (NASA<\/a>, ESA<\/a>, CNES, <\/a>ANR<\/a>, Institut Polaire Fran\u00e7ais<\/a>)<\/p>\n

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ENSEIGNEMENT<\/h2>\n

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Enseignant en Physiologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Caen Normandie<\/p>\n

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Enseignant en Master Activit\u00e9s Physiques Appliqu\u00e9es \u00e0 la Sant\u00e9, Universit\u00e9 de Caen Normandie<\/p>\n

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Enseignant en Master Science du Comportement, Universit\u00e9 de Caen Normandie<\/p>\n

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Enseignant \u00e0 l‘Ecole de Formation des Infirmiers Anesth\u00e9sistes du CHU de CAEN (IADE)<\/a><\/p>\n

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Enseignant \u00e0 l’ Institut de Formation en Masso-kin\u00e9sith\u00e9rapie de L’Universit\u00e9 de CAEN<\/a><\/p>\n

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ACTIVITES COMPLEMENTAIRES<\/h2>\n

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Editeur invit\u00e9 pour Frontiers in Integrative Neurosciences<\/strong><\/p>\n

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Editeur invit\u00e9 pour\u00a0Frontiers in Psychology<\/strong><\/p>\n

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Reviewer r\u00e9gulier dans plus de 15 journaux scientifiques (Scientific Reports, Communications Biology, Neuropsychologia, J Neurophysiol, J Neurol Ped., J Physiol. Pharmacol., Aviat Space Env.Med., Medical Hypotheses, Current Opinion in Alzheimer disease, PLOS ONE, JARO, Brain Behavioral Research,etc…).<\/p>\n

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CONSULTATIONS<\/h2>\n

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Consultation pluridisciplinaire Paralysie Faciale<\/p>\n

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Consultation pluridisciplinaire Vertiges<\/p>\n

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COORDONNEES<\/h2>\n

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RPPS: 10002729696<\/p>\n

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Secr\u00e9tariat Service ORL CHU de CAEN : 02.31.06.46.38<\/p>\n

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Mail\u00a0: besnard-s@chu-caen.fr<\/a><\/p>\n

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PARUTIONS<\/h2>\n

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SYSTEME VESTIBULAIRE<\/h4>\n

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Martin T, Dauvilliers Y, Koumar OC, Besnard S<\/strong>, Dauphin F, Bessot N. Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise. Sci Rep. 2019 Dec 5;9(1):18432.<\/p>\n

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Le Gall A, Hilber P, Chesneau C, Bulla J, Toulouse J, Machado ML, Philoxene B, Smith PF, Besnard S<\/strong>. The critical role of vestibular graviception during cognitive-motor development.<\/a> Behav Brain Res. 2019 Oct 17;372:<\/p>\n

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Besnard S<\/strong>, Tighilet B, Chabbert C, Hitier M, Toulouse J, Legall A, Machado ML, Smith PF. Reply to Micarelli et\u00a0al. Commentary on The Balance of Sleep: Role of the Vestibular Sensory System.<\/a> Sleep Med Rev. 2019 Apr;44:87-88<\/p>\n

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Truchet B, Benoit A, Chaillan F, Smith PF, Philoxene B, Guillamin M, Poucet B, Coquerel A, Besnard S<\/strong>.Hippocampal LTP modulation and glutamatergic receptors following vestibular loss. Brain Struct Funct. 2018 Nov 23. doi: 10.1007\/s00429-018-1792-0.<\/p>\n

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Besnard S<\/strong>, Tighilet B, Chabbert C, Hitier M, Toulouse J, Le Gall A, Machado ML, Smith PF.The balance of sleep: Role of the vestibular sensory system. Sleep Med Rev. 2018 ;42:220-228.<\/p>\n

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Hilber P, Cendelin J, Le Gall A, Machado ML, Tuma J, Besnard S<\/strong>. Cooperation of the vestibular and cerebellar networks in anxiety disorders and depression. Prog Neuropsychopharmacol Biol Psychiatry. 2018;89:310-321<\/p>\n

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Hitier M, Sato G, Zhang YF, Zheng Y, Besnard S<\/strong>, Smith PF. Vestibular-related eye movements in the rat following selective electrical stimulation of the vestibular sensors. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2018 Sep 11.<\/p>\n

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Benoit A, Besnard S<\/strong>, Guillamin M, Philoxene B, Sola B, Le Gall A, Machado ML, Toulouse J, Hitier M, Smith PF. Differential regulation of NMDA receptor-expressing neurons in the rat hippocampus and striatum following bilateral vestibular loss demonstrated using flow cytometry. Neurosci Lett. 2018 Sep 14;683:43-47<\/p>\n

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Hitier M, Sato G, Zhang YF, Besnard S<\/strong>, Smith PF. Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus. Neurosci Lett. 2018 Jun 11;677:60-64.<\/p>\n

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Benoit A, Guillamin M, Aitken P, Smith PF, Philoxene B, Sola B, Poulain L, Coquerel A, Besnard S<\/strong>. Flow cytometry for receptor analysis from ex-vivo brain tissue in adult rat. J Neurosci Methods. 2018 Jul 1;304:11-23.<\/p>\n

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Aitken P, Benoit A, Zheng Y, Philoxene B, Le Gall A, Denise P, Besnard S<\/strong>, Smith PF. Hippocampal and striatal M1<\/sub> -muscarinic acetylcholine receptors are down-regulated following bilateral vestibular loss in rats.\u00a0 Hippocampus. 2016 Dec;26(12):1509-1514. doi: 10.1002\/hipo.22651. Epub 2016 Sep 13.<\/p>\n

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Hitier M, Sato G, Zhang YF, Zheng Y, Besnard S<\/strong>, Smith PF, Curthoys IS. Anatomy and surgical approach of rat’s vestibular sensors and nerves. J Neurosci Methods. 2016<\/p>\n

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Besnard S<\/strong>, Lopez C, Brandt T, Denise P, Smith PF. Editorial<\/strong>: The Vestibular System in Cognitive and Memory Processes in Mammalians. Front Integr Neurosci. 2015 Nov 10;9:55.<\/p>\n

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Vignaux G, Besnard S<\/strong>, Denise P, Elefteriou F.The Vestibular System: A Newly Identified Regulator of Bone Homeostasis Acting Through the Sympathetic Nervous System.Curr Osteoporos Rep. 2015 Aug;13(4):198-205.<\/p>\n

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Martin T, Mauvieux B, Bulla J, Quarck G, Davenne D, Denise P, Philoxene B, Besnard S<\/strong>. Vestibular loss disrupts daily rhythms in rats. J Appl Physiol (1985). 2015 118(3):310-8.<\/p>\n

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Hitier M, Besnard S<\/strong>, Smith PF.Vestibular pathways involved in cognition.Front Integr Neurosci. 2014 Jul 23;8:59.<\/p>\n

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Machado ML, Lelong-Boulouard V, Philoxene B, Davis A, Denise P, Besnard S<\/strong>. Vestibular loss promotes procedural response during a spatial task in rats. Hippocampus. 2014<\/p>\n

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Kamsu JM, Constans JM, Lamberton F, Courtheoux P, Denise P, Philoxene B, Coquemont M, Besnard S<\/strong>. Structural layers of ex vivo rat hippocampus at 7T MRI. PLoS One. 2013 Sep 26;8(9)<\/p>\n

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Vignaux G, Besnard S<\/strong>, Ndong J, Philox\u00e8ne B, Denise P, Elefteriou F. Bone remodeling is regulated by inner ear vestibular signals. J Bone Miner Res. 2013<\/p>\n

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Machado ML, Kroichvili N, Freret T, Philox\u00e8ne B, Lelong-Boulouard V, Denise P, Besnard S<\/strong> Spatial and non-spatial performance in mutant mice devoid of otoliths Neurosci Lett. 2012; 522(1):57-61<\/p>\n

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Machado ML, Lelong-Boulouard V, Smith PF, Freret T, Philoxene B, Denise P, Besnard S<\/strong>. Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat. Neuroscience. 2012;218:161-9.<\/p>\n

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Vignaux G, Chabbert C, Gaboyard-Niay S, Travo C, Machado ML, Denise P, Comoz F, Hitier M, Landemore G, Philox\u00e8ne B, Besnard S<\/strong>.Evaluation of the chemical model of vestibular lesions induced by arsanilate in rats. Toxicol Appl Pharmacol. 2012 Jan 1;258(1):61-71. Epub 2011 Oct 14.<\/p>\n

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Besnard S<\/strong>, Machado ML, Vignaux G, Boulouard M, Coquerel A, Bouet V, Freret T, Denise P, Lelong-Boulouard V. Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors. Hippocampus. \u00a02012 22(4):814-26<\/p>\n

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Hitier M, Besnard S<\/strong>, Vignaux G, Denise P, Moreau S. The ventrolateral surgical approach to labyrinthectomy in rats: anatomical description and clinical consequences. Surg Radiol Anat. 2010 Jul 4.<\/p>\n

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PHYSIOLOGIE ET NEUROSCIENCES EN MILIEUX EXTREMES<\/h4>\n

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Balestra C, Kot J, Efrati S, Guerrero F, Blatteau JE, Besnard S<\/strong>. Editorial: Extreme Environments in Movement Science and Sport Psychology.<\/a> Front Psychol. 2018; 9:2391<\/p>\n

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Balestra C, Machado ML, Theunissen S, Balestra A, Cialoni D, Clot C, Besnard S<\/strong>, Kammacher L, Delzenne J, Germonpr\u00e9 P, Laf\u00e8re P. Critical Flicker Fusion Frequency: A Marker of Cerebral Arousal During Modified Gravitational Conditions Related to Parabolic Flights. Front Physiol. 2018 Oct 2;9:1403. doi: 10.3389\/fphys.2018.01403. eCollection 2018.<\/p>\n

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Zheng Y, Gliddon CM, Aitken P, Stiles L, Machado ML, Philoxene B, Denise P, Smih PF, Besnard S<\/strong>. Effects of acute altered gravity during parabolic flight and\/or vestibular loss on cell proliferation in the rat dentate gyrus. Neurosci Lett. 2017 Jul 27;654:120-124.<\/p>\n

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Golding JF, Paillard AC, Normand H, Besnard S<\/strong>, Denise P. Prevalence, Predictors, and Prevention of Motion Sickness in Zero-G Parabolic Flights. Aerosp Med Hum Perform. 2017 Jan 1;88(1):3-9<\/p>\n

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Chazalviel L, Blatteau JE, Vall\u00e9e N, Risso JJ, Besnard S<\/strong>, Abraini JH. Effects of normobaric versus<\/em> hyperbaric oxygen on cell injury induced by oxygen and glucose deprivation in acute brain slices. Med Gas Res. 2016 Oct 14;6(3):169-173. eCollection 2016 Jul-Sep.<\/p>\n

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Chazalviel L, Haelewyn B, Degoulet M, Blatteau JE, Vall\u00e9e N, Risso JJ, Besnard S<\/strong>, Abraini JH. Hyperbaric oxygen increases tissue-plasminogen activator-induced thrombolysis in vitro<\/em>, and reduces ischemic brain damage and edema in rats subjected to thromboembolic brain ischemia. Med Gas Res. 2016 Jul 11;6(2):64-69. eCollection 2016 Apr-Jun.<\/p>\n

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Chazalviel L, David HN, Haelewyn B, Blatteau JE, Vall\u00e9e N, Risso JJ, Besnard S<\/strong>, Abraini JH. The underestimated effect of normobaric hyperoxia on cerebral blood flow and its relationship to neuroprotection. Brain. 2016 Nov 1;139(11):e62<\/p>\n

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Luxa N, Salanova M, Schiffl G, Gutsmann M, Besnard S<\/strong>, Denise P, Clarke A, Blottner D.Increased myofiber remodelling and NFATc1-myonuclear translocation in rat postural skeletal muscle after experimental vestibular differentiation. J Vestib Res. 2013<\/p>\n

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Arbeille P, Besnard S<\/strong>, Kerbeci P, Monty DM Portal vein cros-sectional area flow and orthostatic tolerance : a 90-day bed rest study. J Appl Physiol<\/u><\/em>, 2005<\/strong>;99(5):1853-7<\/p>\n

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Arbeille P, Kerbeci P, Besnard S<\/strong>, Montoya A, Dupui P. Influence of eye closing on the cardiovascular response to stand test on stable and unstable platforms. J Gravit Physiol.<\/u><\/em> 2004 <\/strong>;11(2):P85-6.<\/p>\n

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Besnard S<\/strong>, Roumy J, Tobal N, Herault S, Porcher M, Boulay J, Arbeille P Venous stagnation induced by 7 days in HDT, in the cerebral, ophtalmic, renal and splanchnic territories. J Gravit Physiol.<\/u><\/em> 2002<\/strong>;9(1):75-6.<\/p>\n

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Roumy J, Herault S, Tobal N, Besnard S<\/strong>, Arbeille P Effect of a venotonic agent on the main arteries and veins during a 5 day HDT. Acta Astronaut<\/u><\/em>. 2001<\/strong> ;49(3-10):161-6.<\/p>\n

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Arbeille P, Herault S, Roumy J, Porcher M, Besnard S<\/strong>, Vieyres P. 3D realtime echography and echography assisted by a robotic arm for investigating astronauts in the ISS from the ground. J Gravit Physiol.<\/u><\/em> 2001<\/strong>; 8(1):143-4.<\/p>\n

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NEUROPHYSIOLOGIE ET DEVELOPEMENT TECHNOLOGIQUE<\/h4>\n

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Machado ML, Lef\u00e8vre N, Philoxene B, Le Gall A, Madeleine S, Fleury P, Smith PF, Besnard S. <\/strong>New software dedicated to virtual mazes for human cognitive investigations.<\/a> J Neurosci Methods. 2019 Nov 1;327<\/p>\n

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Dupuy EG, Leconte P, Vlamynck E, Sultan A, Chesneau C, Denise P, Besnard S<\/strong>, Bienvenu B, Decker LM.Ehlers-Danlos Syndrome, Hypermobility Type: Impact of Somatosensory Orthoses on Postural Control (A Pilot Study).Front Hum Neurosci. 2017 Jun 8;11:283<\/p>\n

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Burbaud P, Clair AH, Langbour N, Fernandez-Vidal S, Goillandeau M, Michelet T, Bardinet E, Ch\u00e9reau I, Durif F, Polosan M, Chabard\u00e8s S, Fontaine D, Magni\u00e9-Mauro MN, Houeto JL, Bataille B, Millet B, V\u00e9rin M, Baup N, Krebs MO, Cornu P, Pelissolo A, Arbus C, Simonetta-Moreau M, Yelnik J, Welter ML, Mallet L; French Stimulation dans le Trouble Obsessionnel Compulsif Study Group.<\/strong> Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder. Brain. 2013 Jan<\/p>\n

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Besnard S<\/strong>, Khemiri H, Masse F, Denise P, Verdaguer M, Gestreau C. Differential respiratory control of the upper airway and diaphragm muscles induced by 5-HT1A receptor ligands.<\/a> Sleep Breath. 2011 Jan 9<\/p>\n

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Besnard S,<\/strong> Decressac M, Jaber M, Denise P, Gaillard G In vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson\u2019s disease pour Neuroreport<\/u><\/em> 2010 12;21(7):485-9<\/p>\n

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Gaillard A, Decressac M, Frapp\u00e9 I, Fernagut PO, Prestoz L, Besnard S<\/strong>, Jaber M. Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants. Neurobiol Dis. 2009; 35(3):477-88.<\/p>\n

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Besnard S<\/strong>, Denise P, Cappelin B, Dutschmann M, Gestreau C.Stimulation of the rat medullary raphe nuclei induces differential responses in respiratory muscle activity. Respir Physiol Neurobiol.<\/u><\/em> 2009; 165(2-3):208-14.<\/p>\n

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Besnard S<\/strong>, Masse F, Verdaguer M, Cappelin B, Meurice JC, Gestreau C\u00a0\u00a0 Time and dose-related effects of three 5-HT receptor ligands on the genioglossus activity in anesthetized and conscious rats\u00a0 Sleep and Breathing<\/u><\/em> 2007<\/strong> 11(4):275-84.<\/p>\n

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Besnard S.<\/strong> Neurological control of the upper airways: new therapeutic leads?
Rev Mal Respir.<\/u><\/em> 2006<\/strong>; Spec No 2:7S87-7S89.<\/p>\n

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Besnard S<\/strong>, Philippot M, Herv\u00e9 Ph, Porcher M, Arbeille Ph, Vascular distribution of an ultrasound contrast agent used to simulate decompression bubbles\u00a0 Aviat Space Environ Med<\/u><\/em>. 2006<\/strong> ;77(8):846-51.<\/p>\n

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Besnard S<\/strong>, Beaume A, Gil R, Oriot D, Loiseau MN Hashimoto\u2019s encephalopathy in a eleven-years-old adolescent treated with Immunoglobulin Therapy\u00a0\u00a0 J Pediatr Neurol<\/u><\/em> 2006<\/strong>; 4(3): 187-193<\/p>\n

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Paquereau J, Besnard S<\/strong>, Stal V, Neau JP, Meurice JC. Polysomnographic aspects of sleep and respiration in the normal subject Rev Mal Respir.<\/u><\/em> 2004<\/strong>;21(2 Pt 2):S13-25.<\/p>\n

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Fouks JD, Besnard S<\/strong>, Signac L, Meurice JC, Neau JP, Paquereau J\u00a0 Do robots need to sleep? Neurophysiol Clin.<\/u><\/em> 2004<\/strong>;34(2):59-70.<\/p>\n

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Jeanty P, Besnard S<\/strong>, Arnold A,\u00a0 Turner C, Crum P\u00a0\u00a0\u00a0 Air-contrast sonohysterography as a first step assessment of tubal patency. J Ultrasound Med<\/u><\/em>. 2000<\/strong>;19(8):519-27.<\/p>\n

 <\/p>\n

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Explorations vestibulaires et neurophysiologiques FORMATION ET TITRES Ma\u00eetre de Conf\u00e9rence des Universit\u00e9s (M.C.U.) Praticien Hospitalier (P.H.) Docteur en M\u00e9decine (M.D.) Docteur en Neuroscience\u00a0 (Ph.D) Habilitation \u00e0 Diriger les Recherches (HDR) Ancien Assistant des H\u00f4pitaux Ancien Interne des H\u00f4pitaux Capacit\u00e9 de M\u00e9decine A\u00e9ronautique et Spatiale D.I.U. de M\u00e9decine Subaquatique et Hyperbare   SOCIETES SAVANTES Membre de […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

FORMATION ET TITRES<\/h2>\n\n\n\n

Ma\u00eetre de Conf\u00e9rence des Universit\u00e9s (M.C.U.)<\/p>\n\n\n\n

Praticien Hospitalier (P.H.)<\/p>\n\n\n\n

Docteur en M\u00e9decine (M.D.)<\/p>\n\n\n\n

Docteur en Neuroscience  (Ph.D)<\/p>\n\n\n\n

Habilitation \u00e0 Diriger les Recherches (HDR)<\/p>\n\n\n\n

Ancien Assistant des H\u00f4pitaux<\/p>\n\n\n\n

Ancien Interne des H\u00f4pitaux<\/p>\n\n\n\n

Capacit\u00e9 de M\u00e9decine A\u00e9ronautique et Spatiale<\/p>\n\n\n\n

D.I.U. de M\u00e9decine Subaquatique et Hyperbare<\/p>\n\n\n\n

SOCIETES SAVANTES<\/h2>\n\n\n\n

Membre de la Soci\u00e9t\u00e9 Internationale d'Otoneurologie<\/a><\/p>\n\n\n\n

Membre du comit\u00e9 de pilotage du  Groupe De Recherche \"Vertige\" (GDR)<\/a><\/p>\n\n\n\n

Membre du conseil Scientifique de la Soci\u00e9t\u00e9 de Physiologie<\/a><\/p>\n\n\n\n

Membre du conseil scientifique de l'Adaptation Institute<\/a><\/p>\n\n\n\n

DISCIPLINES<\/h2>\n\n\n\n

Physiologie<\/p>\n\n\n\n

Neurophysiologie et M\u00e9decine en milieux extr\u00eames<\/p>\n\n\n\n

Explorations Vestibulaires<\/p>\n\n\n\n

T\u00e9l\u00e9m\u00e9decine<\/p>\n\n\n\n

RECHERCHE<\/h2>\n\n\n\n

Chercheur au Laboratoire de Neurosciences Sensorielles et Cognitives (CNRS- Aix-Marseille)<\/a><\/p>\n\n\n\n

Ancien Chercheur \u00e0 INSERM U 1075 - COMETE<\/em> - \u00abCOgnition, Mobilit\u00e9, Equilibre, TEmporalit\u00e9 \u00bb<\/a><\/p>\n\n\n\n

Investigateur Principal pour diff\u00e9rents programmes de recherche (NASA<\/a>, ESA<\/a>, CNES, <\/a>ANR<\/a>, Institut Polaire Fran\u00e7ais<\/a>)<\/p>\n\n\n\n

ENSEIGNEMENT<\/h2>\n\n\n\n

Enseignant en Physiologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Caen Normandie<\/p>\n\n\n\n

Enseignant en Master Activit\u00e9s Physiques Appliqu\u00e9es \u00e0 la Sant\u00e9, Universit\u00e9 de Caen Normandie<\/p>\n\n\n\n

Enseignant en Master Science du Comportement, Universit\u00e9 de Caen Normandie<\/p>\n\n\n\n

Enseignant \u00e0 l'Ecole de Formation des Infirmiers Anesth\u00e9sistes du CHU de CAEN (IADE)<\/a><\/p>\n\n\n\n

Enseignant \u00e0 l' Institut de Formation en Masso-kin\u00e9sith\u00e9rapie de L'Universit\u00e9 de CAEN<\/a><\/p>\n\n\n\n

ACTIVITES COMPLEMENTAIRES<\/h2>\n\n\n\n

Editeur invit\u00e9 pour Frontiers in Integrative Neurosciences<\/strong><\/p>\n\n\n\n

Editeur invit\u00e9 pour Frontiers in Psychology<\/strong><\/p>\n\n\n\n

Reviewer r\u00e9gulier dans plus de 15 journaux scientifiques (Scientific Reports, Communications Biology, Neuropsychologia, J Neurophysiol, J Neurol Ped., J Physiol. Pharmacol., Aviat Space Env.Med., Medical Hypotheses, Current Opinion in Alzheimer disease, PLOS ONE, JARO, Brain Behavioral Research,etc...).<\/p>\n\n\n\n

CONSULTATIONS<\/h2>\n\n\n\n

Consultation pluridisciplinaire Paralysie Faciale<\/p>\n\n\n\n

Consultation pluridisciplinaire Vertiges<\/p>\n\n\n\n

COORDONNEES<\/h2>\n\n\n\n

RPPS: 10002729696<\/p>\n\n\n\n

Secr\u00e9tariat Service ORL CHU de CAEN : 02.31.06.46.38<\/p>\n\n\n\n

Mail : besnard-s@chu-caen.fr<\/a><\/p>\n\n\n\n

PARUTIONS<\/h2>\n\n\n\n

SYSTEME VESTIBULAIRE<\/h4>\n\n\n\n

Martin T, Dauvilliers Y, Koumar OC, Besnard S<\/strong>, Dauphin F, Bessot N. Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise. Sci Rep. 2019 Dec 5;9(1):18432.<\/p>\n\n\n\n

Le Gall A, Hilber P, Chesneau C, Bulla J, Toulouse J, Machado ML, Philoxene B, Smith PF, Besnard S<\/strong>. The critical role of vestibular graviception during cognitive-motor development.<\/a> Behav Brain Res. 2019 Oct 17;372:<\/p>\n\n\n\n

Besnard S<\/strong>, Tighilet B, Chabbert C, Hitier M, Toulouse J, Legall A, Machado ML, Smith PF. Reply to Micarelli et al. Commentary on The Balance of Sleep: Role of the Vestibular Sensory System.<\/a> Sleep Med Rev. 2019 Apr;44:87-88<\/p>\n\n\n\n

Truchet B, Benoit A, Chaillan F, Smith PF, Philoxene B, Guillamin M, Poucet B, Coquerel A, Besnard S<\/strong>.Hippocampal LTP modulation and glutamatergic receptors following vestibular loss. Brain Struct Funct. 2018 Nov 23. doi: 10.1007\/s00429-018-1792-0.<\/p>\n\n\n\n

Besnard S<\/strong>, Tighilet B, Chabbert C, Hitier M, Toulouse J, Le Gall A, Machado ML, Smith PF.The balance of sleep: Role of the vestibular sensory system. Sleep Med Rev. 2018 ;42:220-228.<\/p>\n\n\n\n

Hilber P, Cendelin J, Le Gall A, Machado ML, Tuma J, Besnard S<\/strong>. Cooperation of the vestibular and cerebellar networks in anxiety disorders and depression. Prog Neuropsychopharmacol Biol Psychiatry. 2018;89:310-321<\/p>\n\n\n\n

Hitier M, Sato G, Zhang YF, Zheng Y, Besnard S<\/strong>, Smith PF. Vestibular-related eye movements in the rat following selective electrical stimulation of the vestibular sensors. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2018 Sep 11.<\/p>\n\n\n\n

Benoit A, Besnard S<\/strong>, Guillamin M, Philoxene B, Sola B, Le Gall A, Machado ML, Toulouse J, Hitier M, Smith PF. Differential regulation of NMDA receptor-expressing neurons in the rat hippocampus and striatum following bilateral vestibular loss demonstrated using flow cytometry. Neurosci Lett. 2018 Sep 14;683:43-47<\/p>\n\n\n\n

Hitier M, Sato G, Zhang YF, Besnard S<\/strong>, Smith PF. Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus. Neurosci Lett. 2018 Jun 11;677:60-64.<\/p>\n\n\n\n

Benoit A, Guillamin M, Aitken P, Smith PF, Philoxene B, Sola B, Poulain L, Coquerel A, Besnard S<\/strong>. Flow cytometry for receptor analysis from ex-vivo brain tissue in adult rat. J Neurosci Methods. 2018 Jul 1;304:11-23.<\/p>\n\n\n\n

Aitken P, Benoit A, Zheng Y, Philoxene B, Le Gall A, Denise P, Besnard S<\/strong>, Smith PF. Hippocampal and striatal M1<\/sub> -muscarinic acetylcholine receptors are down-regulated following bilateral vestibular loss in rats.  Hippocampus. 2016 Dec;26(12):1509-1514. doi: 10.1002\/hipo.22651. Epub 2016 Sep 13.<\/p>\n\n\n\n

Hitier M, Sato G, Zhang YF, Zheng Y, Besnard S<\/strong>, Smith PF, Curthoys IS. Anatomy and surgical approach of rat's vestibular sensors and nerves. J Neurosci Methods. 2016<\/p>\n\n\n\n

Besnard S<\/strong>, Lopez C, Brandt T, Denise P, Smith PF. Editorial<\/strong>: The Vestibular System in Cognitive and Memory Processes in Mammalians. Front Integr Neurosci. 2015 Nov 10;9:55.<\/p>\n\n\n\n

Vignaux G, Besnard S<\/strong>, Denise P, Elefteriou F.The Vestibular System: A Newly Identified Regulator of Bone Homeostasis Acting Through the Sympathetic Nervous System.Curr Osteoporos Rep. 2015 Aug;13(4):198-205.<\/p>\n\n\n\n

Martin T, Mauvieux B, Bulla J, Quarck G, Davenne D, Denise P, Philoxene B, Besnard S<\/strong>. Vestibular loss disrupts daily rhythms in rats. J Appl Physiol (1985). 2015 118(3):310-8.<\/p>\n\n\n\n

Hitier M, Besnard S<\/strong>, Smith PF.Vestibular pathways involved in cognition.Front Integr Neurosci. 2014 Jul 23;8:59.<\/p>\n\n\n\n

Machado ML, Lelong-Boulouard V, Philoxene B, Davis A, Denise P, Besnard S<\/strong>. Vestibular loss promotes procedural response during a spatial task in rats. Hippocampus. 2014<\/p>\n\n\n\n

Kamsu JM, Constans JM, Lamberton F, Courtheoux P, Denise P, Philoxene B, Coquemont M, Besnard S<\/strong>. Structural layers of ex vivo rat hippocampus at 7T MRI. PLoS One. 2013 Sep 26;8(9)<\/p>\n\n\n\n

Vignaux G, Besnard S<\/strong>, Ndong J, Philox\u00e8ne B, Denise P, Elefteriou F. Bone remodeling is regulated by inner ear vestibular signals. J Bone Miner Res. 2013<\/p>\n\n\n\n

Machado ML, Kroichvili N, Freret T, Philox\u00e8ne B, Lelong-Boulouard V, Denise P, Besnard S<\/strong> Spatial and non-spatial performance in mutant mice devoid of otoliths Neurosci Lett. 2012; 522(1):57-61<\/p>\n\n\n\n

Machado ML, Lelong-Boulouard V, Smith PF, Freret T, Philoxene B, Denise P, Besnard S<\/strong>. Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat. Neuroscience. 2012;218:161-9.<\/p>\n\n\n\n

Vignaux G, Chabbert C, Gaboyard-Niay S, Travo C, Machado ML, Denise P, Comoz F, Hitier M, Landemore G, Philox\u00e8ne B, Besnard S<\/strong>.Evaluation of the chemical model of vestibular lesions induced by arsanilate in rats. Toxicol Appl Pharmacol. 2012 Jan 1;258(1):61-71. Epub 2011 Oct 14.<\/p>\n\n\n\n

Besnard S<\/strong>, Machado ML, Vignaux G, Boulouard M, Coquerel A, Bouet V, Freret T, Denise P, Lelong-Boulouard V. Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors. Hippocampus.  2012 22(4):814-26<\/p>\n\n\n\n

Hitier M, Besnard S<\/strong>, Vignaux G, Denise P, Moreau S. The ventrolateral surgical approach to labyrinthectomy in rats: anatomical description and clinical consequences. Surg Radiol Anat. 2010 Jul 4.<\/p>\n\n\n\n

PHYSIOLOGIE ET NEUROSCIENCES EN MILIEUX EXTREMES<\/h4>\n\n\n\n

Balestra C, Kot J, Efrati S, Guerrero F, Blatteau JE, Besnard S<\/strong>. Editorial: Extreme Environments in Movement Science and Sport Psychology.<\/a> Front Psychol. 2018; 9:2391<\/p>\n\n\n\n

Balestra C, Machado ML, Theunissen S, Balestra A, Cialoni D, Clot C, Besnard S<\/strong>, Kammacher L, Delzenne J, Germonpr\u00e9 P, Laf\u00e8re P. Critical Flicker Fusion Frequency: A Marker of Cerebral Arousal During Modified Gravitational Conditions Related to Parabolic Flights. Front Physiol. 2018 Oct 2;9:1403. doi: 10.3389\/fphys.2018.01403. eCollection 2018.<\/p>\n\n\n\n

Zheng Y, Gliddon CM, Aitken P, Stiles L, Machado ML, Philoxene B, Denise P, Smih PF, Besnard S<\/strong>. Effects of acute altered gravity during parabolic flight and\/or vestibular loss on cell proliferation in the rat dentate gyrus. Neurosci Lett. 2017 Jul 27;654:120-124.<\/p>\n\n\n\n

Golding JF, Paillard AC, Normand H, Besnard S<\/strong>, Denise P. Prevalence, Predictors, and Prevention of Motion Sickness in Zero-G Parabolic Flights. Aerosp Med Hum Perform. 2017 Jan 1;88(1):3-9<\/p>\n\n\n\n

Chazalviel L, Blatteau JE, Vall\u00e9e N, Risso JJ, Besnard S<\/strong>, Abraini JH. Effects of normobaric versus<\/em> hyperbaric oxygen on cell injury induced by oxygen and glucose deprivation in acute brain slices. Med Gas Res. 2016 Oct 14;6(3):169-173. eCollection 2016 Jul-Sep.<\/p>\n\n\n\n

Chazalviel L, Haelewyn B, Degoulet M, Blatteau JE, Vall\u00e9e N, Risso JJ, Besnard S<\/strong>, Abraini JH. Hyperbaric oxygen increases tissue-plasminogen activator-induced thrombolysis in vitro<\/em>, and reduces ischemic brain damage and edema in rats subjected to thromboembolic brain ischemia. Med Gas Res. 2016 Jul 11;6(2):64-69. eCollection 2016 Apr-Jun.<\/p>\n\n\n\n

Chazalviel L, David HN, Haelewyn B, Blatteau JE, Vall\u00e9e N, Risso JJ, Besnard S<\/strong>, Abraini JH. The underestimated effect of normobaric hyperoxia on cerebral blood flow and its relationship to neuroprotection. Brain. 2016 Nov 1;139(11):e62<\/p>\n\n\n\n

Luxa N, Salanova M, Schiffl G, Gutsmann M, Besnard S<\/strong>, Denise P, Clarke A, Blottner D.Increased myofiber remodelling and NFATc1-myonuclear translocation in rat postural skeletal muscle after experimental vestibular differentiation. J Vestib Res. 2013<\/p>\n\n\n\n

Arbeille P, Besnard S<\/strong>, Kerbeci P, Monty DM Portal vein cros-sectional area flow and orthostatic tolerance : a 90-day bed rest study. J Appl Physiol<\/u><\/em>, 2005<\/strong>;99(5):1853-7<\/p>\n\n\n\n

Arbeille P, Kerbeci P, Besnard S<\/strong>, Montoya A, Dupui P. Influence of eye closing on the cardiovascular response to stand test on stable and unstable platforms. J Gravit Physiol.<\/u><\/em> 2004 <\/strong>;11(2):P85-6.<\/p>\n\n\n\n

Besnard S<\/strong>, Roumy J, Tobal N, Herault S, Porcher M, Boulay J, Arbeille P Venous stagnation induced by 7 days in HDT, in the cerebral, ophtalmic, renal and splanchnic territories. J Gravit Physiol.<\/u><\/em> 2002<\/strong>;9(1):75-6.<\/p>\n\n\n\n

Roumy J, Herault S, Tobal N, Besnard S<\/strong>, Arbeille P Effect of a venotonic agent on the main arteries and veins during a 5 day HDT. Acta Astronaut<\/u><\/em>. 2001<\/strong> ;49(3-10):161-6.<\/p>\n\n\n\n

Arbeille P, Herault S, Roumy J, Porcher M, Besnard S<\/strong>, Vieyres P. 3D realtime echography and echography assisted by a robotic arm for investigating astronauts in the ISS from the ground. J Gravit Physiol.<\/u><\/em> 2001<\/strong>; 8(1):143-4.<\/p>\n\n\n\n

NEUROPHYSIOLOGIE ET DEVELOPEMENT TECHNOLOGIQUE<\/h4>\n\n\n\n

Machado ML, Lef\u00e8vre N, Philoxene B, Le Gall A, Madeleine S, Fleury P, Smith PF, Besnard S. <\/strong>New software dedicated to virtual mazes for human cognitive investigations.<\/a> J Neurosci Methods. 2019 Nov 1;327<\/p>\n\n\n\n

Dupuy EG, Leconte P, Vlamynck E, Sultan A, Chesneau C, Denise P, Besnard S<\/strong>, Bienvenu B, Decker LM.Ehlers-Danlos Syndrome, Hypermobility Type: Impact of Somatosensory Orthoses on Postural Control (A Pilot Study).Front Hum Neurosci. 2017 Jun 8;11:283<\/p>\n\n\n\n

Burbaud P, Clair AH, Langbour N, Fernandez-Vidal S, Goillandeau M, Michelet T, Bardinet E, Ch\u00e9reau I, Durif F, Polosan M, Chabard\u00e8s S, Fontaine D, Magni\u00e9-Mauro MN, Houeto JL, Bataille B, Millet B, V\u00e9rin M, Baup N, Krebs MO, Cornu P, Pelissolo A, Arbus C, Simonetta-Moreau M, Yelnik J, Welter ML, Mallet L; French Stimulation dans le Trouble Obsessionnel Compulsif Study Group.<\/strong> Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder. Brain. 2013 Jan<\/p>\n\n\n\n

Besnard S<\/strong>, Khemiri H, Masse F, Denise P, Verdaguer M, Gestreau C. Differential respiratory control of the upper airway and diaphragm muscles induced by 5-HT1A receptor ligands.<\/a> Sleep Breath. 2011 Jan 9<\/p>\n\n\n\n

Besnard S,<\/strong> Decressac M, Jaber M, Denise P, Gaillard G In vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson\u2019s disease pour Neuroreport<\/u><\/em> 2010 12;21(7):485-9<\/p>\n\n\n\n

Gaillard A, Decressac M, Frapp\u00e9 I, Fernagut PO, Prestoz L, Besnard S<\/strong>, Jaber M. Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants. Neurobiol Dis. 2009; 35(3):477-88.<\/p>\n\n\n\n

Besnard S<\/strong>, Denise P, Cappelin B, Dutschmann M, Gestreau C.Stimulation of the rat medullary raphe nuclei induces differential responses in respiratory muscle activity. Respir Physiol Neurobiol.<\/u><\/em> 2009; 165(2-3):208-14.<\/p>\n\n\n\n

Besnard S<\/strong>, Masse F, Verdaguer M, Cappelin B, Meurice JC, Gestreau C   Time and dose-related effects of three 5-HT receptor ligands on the genioglossus activity in anesthetized and conscious rats  Sleep and Breathing<\/u><\/em> 2007<\/strong> 11(4):275-84.<\/p>\n\n\n\n

Besnard S.<\/strong> Neurological control of the upper airways: new therapeutic leads?
Rev Mal Respir.<\/u><\/em> 2006<\/strong>; Spec No 2:7S87-7S89.<\/p>\n\n\n\n

Besnard S<\/strong>, Philippot M, Herv\u00e9 Ph, Porcher M, Arbeille Ph, Vascular distribution of an ultrasound contrast agent used to simulate decompression bubbles  Aviat Space Environ Med<\/u><\/em>. 2006<\/strong> ;77(8):846-51.<\/p>\n\n\n\n

Besnard S<\/strong>, Beaume A, Gil R, Oriot D, Loiseau MN Hashimoto\u2019s encephalopathy in a eleven-years-old adolescent treated with Immunoglobulin Therapy   J Pediatr Neurol<\/u><\/em> 2006<\/strong>; 4(3): 187-193<\/p>\n\n\n\n

Paquereau J, Besnard S<\/strong>, Stal V, Neau JP, Meurice JC. Polysomnographic aspects of sleep and respiration in the normal subject Rev Mal Respir.<\/u><\/em> 2004<\/strong>;21(2 Pt 2):S13-25.<\/p>\n\n\n\n

Fouks JD, Besnard S<\/strong>, Signac L, Meurice JC, Neau JP, Paquereau J  Do robots need to sleep? Neurophysiol Clin.<\/u><\/em> 2004<\/strong>;34(2):59-70.<\/p>\n\n\n\n

Jeanty P, Besnard S<\/strong>, Arnold A,  Turner C, Crum P    Air-contrast sonohysterography as a first step assessment of tubal patency. J Ultrasound Med<\/u><\/em>. 2000<\/strong>;19(8):519-27.<\/p>\n","_et_gb_content_width":"","ngg_post_thumbnail":0,"footnotes":""},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/orl-chu-caen.fr\/index.php?rest_route=\/wp\/v2\/pages\/4600"}],"collection":[{"href":"https:\/\/orl-chu-caen.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/orl-chu-caen.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/orl-chu-caen.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/orl-chu-caen.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4600"}],"version-history":[{"count":11,"href":"https:\/\/orl-chu-caen.fr\/index.php?rest_route=\/wp\/v2\/pages\/4600\/revisions"}],"predecessor-version":[{"id":6268,"href":"https:\/\/orl-chu-caen.fr\/index.php?rest_route=\/wp\/v2\/pages\/4600\/revisions\/6268"}],"wp:attachment":[{"href":"https:\/\/orl-chu-caen.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}